Mechanisms of Lung Neutrophil Activation
نویسندگان
چکیده
منابع مشابه
Bench-to-bedside review: Acute respiratory distress syndrome – how neutrophils migrate into the lung
Acute lung injury and its more severe form, acute respiratory distress syndrome, are major challenges in critically ill patients. Activation of circulating neutrophils and transmigration into the alveolar airspace are associated with development of acute lung injury, and inhibitors of neutrophil recruitment attenuate lung damage in many experimental models. The molecular mechanisms of neutrophi...
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The underlying mechanisms of lung endothelial injury after intestinal ischemia-reperfusion (I/R) injury are not fully known. Here we investigated the effects of posttreatment with a neutrophil elastase inhibitor (NEI; ONO-5046) on lung injury after intestinal I/R injury in a rat model. Intestinal I/R was produced by 90 min of ischemia followed by either 60 or 240 min of reperfusion. For all exp...
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Positive pressure ventilation with large VTs has been shown to cause release of cytokines, including macrophage inflammatory protein-2 (MIP-2), a functional equivalent of human interleukin-8. The mechanisms regulating ventilation-induced cytokine production are unclear. Based on our previous in vitro model of lung cell stretch, we hypothesized that high VT ventilation-induced MIP-2 production i...
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Leukocyte migration is critical for our survival. Patients with profound neutropenia or congenital disorders of neutrophil function are prone to life-threatening infections [1, 2]. Paradoxically, neutrophil migration and activation in the lungs is widely believed to be one of the fundamental contributing factors to the acute lung injury that occurs in patients with acute respiratory distress sy...
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INTRODUCTION Positive pressure ventilation with large tidal volumes has been shown to cause release of cytokines, including macrophage inflammatory protein-2 (MIP-2), a functional equivalent of human IL-8, and neutrophil infiltration. Hyperoxia has been shown to increase ventilator-induced lung injury, but the mechanisms regulating interaction between a large tidal volume and hyperoxia are uncl...
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